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Veröffentlichungen Prof. Dr. Andreas Bechthold (Stand Juli 2021)


  1. Tsypik O, Makitrynskyy R, Yan X, Koch HG, Paululat T, Bechthold A (2021) Regulatory Control of Rishirilide(s) Biosynthesis in Streptomyces bottropensis. Microorganisms 9(2):374.
  2. Schwarzer P, Flemming S, MacMillan JB, Bechthold A. (2021).  Draft Genome Sequence of Marine Actinobacterium Streptomyces spinoverrucosus SNB-032. Microbiol. Resour. Announc.10 (16): e00028-21
  3. Alali A, Zhang L, Li J, Zuo C, Wassouf D, Yan X, Schwarzer P, Günther S, Einsle O, Bechthold A. 2021. Biosynthesis of the Tricyclic Aromatic Type II Polyketide Rishirilide: New Potential Third Ring Oxygenation after Three Cyclization Steps. Mol Biotechnol 63 (6): 502-514
  4. Ashraf N, Bechthold A, Anwar MA, Ghauri MA, Anjum MS, Khan AN, Akhtar K, Khaliq S. 2021. Production of a broad spectrum streptothricin like antibiotic from halotolerant Streptomyces fimbriatus isolate G1 associated with marine sediments. Folia Microbiol Praha doi: 10.1007/s12223-021-00870-4
  5. Nuzzo D, Makitrynskyy R, Tsypik O, Bechthold A (2021) Identification and Characterization of Four c-di-GMP-Metabolizing Enzymes from Streptomyces ghanaensis ATCC14672 Involved in the Regulation of Morphogenesis and Moenomycin A Biosynthesis. Microorganisms 9 (2): 284-301
  6. Singhvi N, Singh P, Prakash O, Gupta V, Bechthold A, Singh Y, Singh RK, Lal R (2021) Differential mass spectrometry-based proteome analyses unveil major regulatory hubs in rifamycin B production in Amycolatopsis mediterranei. Journal of Proteomics 239:104168-104181
  7. Ashraf N, Bechthold A, Anwar AM, Khaliq S (2020) Draft Genome Sequence of Streptomycessp. Strain BR123, Endowed with Broad-Spectrum Antimicrobial Potential. Microbiology Resource Announcment 9 (41), DOI: 10.1128/MRA.00972-20
  8. Gutacker F, Schmidt-Bohli Y, Strobel T, Qiub D, Jessen H, Paululat T, Bechthold A (2020). Identification and characterization of a novel N- and O- glycosyltransferase from Saccharopolyspora erythraea that catalyzes the formation of α- and β-glycosidic bonds. Molecules 25(15): 3400-3410
  9. Ma Z, Hu Y, Liao Z, Jie X, Xu X, Bechthold A, Yu YX (2020) Cloning and overexpression of the toy cluster for titer improvement of toyocamycin in Streptomyces diastatochromogenes. Frontiers Microbiology, 11: 2074-2087
  10. Nuzzo D, Makitrynskyy R, Tsypik O, Bechthold A (2020) Cyclic di-GMP cyclase SSFG_02181 from Streptomyces ghanaensis ATCC14672 regulates antibiotic biosynthesis and morphological differentiation in streptomycetes. Scientific Reports 10(1):12021-12036
  11.  Singhvi N, Gupta V, Singh RK, Bechthold A, Singh Y, Lal R. (2020). Prediction of transcription factors and their involvement in regulating rifamycin production in Amycolatopsis mediterranei S699. Indian Journal of Microbiol.
  12. Liao J, Xu J, Xu X, Ma Z, Bechthold A, Yu X (2020) Promoter reengineering and functional analysis of toy cluster to enhance the production of toyocamycin in Streptomyces diastatochromogenes. Applied Microbiology and Biotechnology, submitted.
  13. Song Z, Ma Z, Bechthold A, Yu X (2020) Effects of addition of elicitors on rimocidin biosynthesis in Streptomyces rimosus M527. Appl Microbiol Biotechnol. doi: 10.1007/s00253-020-10565-4.
  14. Liao Z, Song Z, Xu J, Ma Z, Bechthold A, Yu X (2020) Identification of a gene from Streptomyces rimosus M527 negatively affecting antibiotic biosynthesis and morphological differentiation. Applied Microbiol Biotechnol 104 (23): 10191-10202
  15. Bernhardt M, Berman S, Zechel D, Bechthold A (2020) Role of Two Exceptional trans Adenylation Domains and MbtH-like Proteins in the Biosynthesis of the Nonribosomal Peptide WS9324A from Streptomyces calvus ATCC 13382. Chembiochem. doi: 10.1002/cbic.202000142.
  16. Schwarzer P, Tsypik O], Alali A, Wunsch-Palasis J, Heitzler T, Derochfort J, Zuo C, Bernhardt M, Yan X, Paululat T, Bechthold A (2020). Early steps in the biosynthetic pathway of rishirilide B. Molecules 25(8), 1955;
  17. Tsypik O, Makitrynskyy R, Frensch B, Zechel DL, Paululat T, Teufel R, Bechthold A (2020) Oxidative carbon backbone rearrangement in rishirilide biosynthesis. JACS 142(13), 5913-5917.
  18. Makitrynskyy R, Tsypik O, Nuzzo D, Paululat T, Zechel DL, Bechthold A (2020) Secondary nucleotide messenger c-di-GMP exerts a global control on natural product biosynthesis in streptomycetes. Nucleic Acids Res. 48(3): 1583-1598.
  19. Mehnaz S, Bechthold A, Gross H (2020) Draft Genome Sequence of Pseudomonas chlororaphis subsp. aurantiaca ARS-38, a Bacterial Strain with Plant Growth Promotion Potential, Isolated from the Rhizosphere of Cotton in Pakistan. Microbiology Resource Announcements 9 (3): eO1398-19.
  20. Song ZQ, Liao ZJ, Hu YF, Ma Z, Bechthold A, Yu XP (2019) Development and optimization of an intergeneric conjugation system and analysis of promoter activity in Streptomyces rimosus M527. J Zhejiang Univ Sci B. 20(11):891-900.
  21. Husain SM, Präg A, Linnenbrink A, Bechthold A, Müller M (2019) Insights into the Role of Ketoreductases in the Biosynthesis of Partially Reduced Bacterial Aromatic Polyketides. Chembiochem. Sep doi: 10.1002/cbic.201900357.
  22. Zhu J, Zhang S, Zechel DL, Paululat T, Bechthold A (2019) Rational Design of Hybrid Natural Products by Utilizing the Promiscuity of an Amide Synthetase. ACS Chem Biol. 14(8):1793-1801.
  23. Xu J, Song Z, Xu X, Ma Z, Bechthold A, Yu X (2019) ToyA, a positive pathway-specific regulator for toyocamycin biosynthesis in Streptomyces diastatochromogenes 1628. Appl Microbiol Biotechnol. Jun 29. doi: 10.1007/s00253-019-09959-w.
  24. Sarwar A, Latif Z, Zhang S, Hao J, Bechthold A (2019) A Potential Biocontrol Agent Streptomyces violaceusniger AC12AB for Managing Potato Common Scab. Front Microbiol. 10:202-212.
  25. Zhang S, Klementz D, Zhu J, Makitrynskyy R, Ola Pasternak AR, Günther S, Zechel DL, Bechthold A (2019) Genome mining reveals the origin of a bald phenotype and a cryptic nucleocidin gene cluster in Streptomyces asterosporus DSM 41452. J. Biotechnol. 292:23-31. doi: 10.1016/j.jbiotec.2018.12.016.
  26. Zhao Y, Song Z, Ma Z, Bechthold A, Yu (2019) Sequential improvement of rimocidin production in Streptomyces rimosus M527 by introduction of cumulative drug-resistance mutations. J Ind Microbiol Biotechnol. 46(5):697-708.
  27. Zhao Y, Lu D., Bechthold A, Ma Z, Xiao-ping Y (2018) Impact of otrA expression on morphological differentiation, actinorhodin production and resistance to aminoglycosides in Streptomyces coelicolor M145. J Zhejiang Univ Sci B. 19(9): 708-717.
  28. Wang J, Xu J, Luo S, Ma Z, Bechthold A, Yu X (2018) AdpA sd , a Positive Regulator for Morphological Development and Toyocamycin Biosynthesis in Streptomyces diastatochromogenes 1628. Curr Microbiol. 2018 75(10):1345-1351. doi: 10.1007/s00284-018-1529-6.
  29. Sarwar A, Latif Z, Zhang S, Zhu J, Zechel DL, Bechthold A (2018) Biological Control of Potato Common Scab With Rare Isatropolone C Compound Produced by Plant Growth Promoting Streptomyces A1RT. Front Microbiol. 9:1126-118.
  30. Schwarzer P, Wunsch-Palasis J, Bechthold A, Paululat T (2018) Biosynthesis of rishirilid B. Antibiotics (Basel) 7: 20-28.
  31. Guo X, Crnovcic I, Chang CY, Luo J, Lohman JR, Papinski M, Bechthold A, Horsman GP, Shen B. (2018) PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates. Biochemistry. 57(6):1003-1011.
  32. Zhang S, Zhu J, Zechel D, Jessen-Trefzer C, Eastman RT, Paululat T, Bechthold, A (2018) Novel WS9326A derivatives and one novel Annimycin derivative with antimalarial activity are produced by Streptomyces asterosporus DSM 41452 and its mutant. ChemBioChem 19(3):272-279.
  33. Samra S, Tokovenko B, Kaszubowska M, Makitrynskyy R, Alali A, Schmidt Y, Welle E, Gross G, Paululat T, Luzhetskyy A, Bechthold A (2018) Insight into Saccharothrix espanaensis Grown in Different Media: Transcriptome and Natural Product Analysis. Nat Prod Chem Res 6: 333-336.
  34. Greule A, Marolt M, Deubel D, Peintner I, Zhang S, Jessen-Trefzer C, De Ford C, Burschel S, Li SM, Friedrich T, Merfort I, Lüdeke S, Bisel P, Müller M, Paululat T, Bechthold A (2017) Wide Distribution of Foxicin Biosynthetic Gene Clusters in Streptomyces Strains - An Unusual Secondary Metabolite with Various Properties. Front Microbiol. 8:221-234.
  35. Greule A, Zhang S, Paululat T, Bechthold A (2017) From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028. J Vis Exp. 13: 119.
  36. Xu X, Wang J, Bechthold A, Ma Z, Yu X (2017) Selection of an efficient promoter and its application in toyocamycin production improvement in Streptomyces diastatochromogenes 1628. World J Microbiol Biotechnol. 33(2):30-38.
  37. Greule A, Intra B, Flemming S, Rommel MG, Panbangred W, Bechthold A (2016) The Draft Genome Sequence of Actinokineospora bangkokensis 44EHWT Reveals the Biosynthetic Pathway of the Antifungal Thailandin Compounds with Unusual Butylmalonyl-CoA Extender Units. Molecules 23(11). pii: E1607.PMID: 27886115.
  38. Manderscheid N, Bilyk B, Busche T, Kalinowski J, Paululat T, Bechthold A, Petzke L, Luzhetskyy A (2016) An influence of the copy number of biosynthetic gene clusters on the production level of antibiotics in a heterologous host. J Biotechnol. 20;232, 110-107. doi: 10.1016/j.jbiotec.2016.05.038
  39. Intra B, Greule A, Bechthold A, Euanorasetr J, Paululat T, Panbangred W (2016)     Thailandins A and B, New Polyene Macrolactone Compounds Isolated from Actinokineospora bangkokensis Strain 44EHWT, Possessing Antifungal Activity against Anthracnose Fungi and Pathogenic Yeasts. J Agric Food Chem. 64(25):5171-5179. doi: 10.1021/acs.jafc.6b01119.
  40. Zhang S, Zhu J, Lui T, Samra S, Pan H, Bai J, Hua H, Bechthold A (2016) Myrothecoside, A Novel Glycosylated Polyketide From the Terrestrial Fungus Myrothecium sp. GS-17. Helvetica Chimica Acta 99, 215-219.
  41. Bilyk O, Brötz E, Tokovenko B, Bechthold A, Paululat T, Luzhetskyy A (2016) New simocyclinones: surprising evolutionary and biosynthetic insights. ACS Chemical Biology 11(1):241-50.
  42. Ma Z, Luo S, Xu X, Bechthold A, Yu X (2016) Characterization of representative rpoB gene mutations leading to a significant change in toyocamycin production of Streptomyces diastatochromogenes 1628. J Ind Microbiol Biotechnol. 4, 463-471. doi: 10.1007/s10295-015-1732-4.
  43. Klementz D, Döring K, Lucas X, Telukunta K, Erxleben A, Deubel D, Erber A, Santillana I, Thomas O, Bechthold A, Günther S (2016) StreptomeDB 2.0 – an extended resource of natural products produced by streptomycetes. Nucleic Acids Res. 44(D1):D509-514. doi: 10.1093/nar/gkv1319.
  44. Kroeger J, Vörös A, Simm R, Hassan K, Paulsen I, Bechthold A, Henderson P, Kolstø A (2015) Bacillus cereus efflux protein BC3310 - a multidrug transporter of the unknown major facilitator family, UMF-2. Front Microbiol. 2015 Oct 12;6:1063. doi: 10.3389/fmicb.2015.01063. eCollection 2015.
  45. Hackl, S, Bechthold, A (2015) The Gene bldA, a Regulator of Morphological Differentiation and Antibiotic Production in Streptomyces. Arch Pharm (Weinheim). 348(7):455-62.
  46. Zhu XM, Hackl S, Thaker MN, Kalan L, Weber C, Urgast DS, Krupp EM, Brewer A, Vanner S, Szawiola A, Yim G, Feldmann J, Bechthold A, Wright GD, Zechel DL (2015) Biosynthesis of the fluorinated Nntural product nucleocidin in Streptomyces calvus is dependent on the bldA-Specified Leu-tRNAUUA molecule. ChemBioChem 17: 2498-2506.
  47. Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO (2015). The Minimum Information about a Biosynthetic Gene cluster (MIBiG) specification. Nat Chem Biol 11(9): 625-631.
  48. Gessner A, Heitzler T, Zhang S, Klaus C, Murillo R, Zhao H, Vanner S, Zechel D, Bechthold A (2015) Changing biosynthetic profiles by expressing bldA in Streptomyces strains. ChemBioChem 16(15): 2244-2252.
  49. Maier S, Heitzler T, Asmus K, Brötz E, Hardter U, Hesselbach K, Paululat T, Bechthold A (2015) Functional Characterization of Different ORFs Including Luciferase-Like Monooxygenase Genes from the Mensacarcin Gene Cluster. Chembiochem. 26;16(8):1175-82.
  50. Tam HK, Härle J, Gerhardt S, Rohr J, Thorson JS, Bigot A, Lutterbeck M, Seiche W, Breit B, Bechthold A, Einsle O (2015) Structural Characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2. Angewandte. 54(9): 2811-2815.
  51. Tao L, Ma Z, Xu X, Bechthold A, Bian Y, Shentu X, Yu X, (2015) Engineering Streptomyces diastatochromogenes 1628 to increase the production of toyocamycin. ENGINEERING IN LIFE SCIENCES   15, (8)_ 779-787.
  52. Brötz E, Bilyka O, Krögera S, Paululat T, Bechthold A, Luzhetskyy A (2014) Amycomycin C and D, new angucyclines from Kitasatospora sp. Tetrahedron Letters, Volume 55 (42): 5771-5773.
  53. Rebets Y, Tokovenko B, Lushchyk I, Rückert C, Zaburannyi N, Bechthold A, Kalinowski J, Luzhetskyy A (2014) Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae. BMC Genomics. 15(1):885.
  54. Ma Z, Tao L, Bechthold A, Shentu X, Bian Y, Yu X (2014) Overexpression of ribosomerecycling factor is responsible for improvement of nucleotide antibiotic-toyocamycin in Streptomyces diastatochromogenes 1628. Appl Microbiol Biotechnol. 11: 5051-5058.
  55. Maier S, Pflüger T, Loesgen S, Asmus K, Brötz E, Paululat T, Zeeck A, Bechthold A (2014) Novel insights into the bioactivity and epoxide formation in mensacarcin by MsnO8. ChemBioChem 15(5):749-56.
  56. Makitrynskyy R, Ostash B, Tsypik O, Rebets Y, Doud E, Meredith T, Luzhetskyy A, Bechthold A, Walker S, Fedorenko V (2013) Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin. Open Biol. 3(10):130121.
  57. Horbal L, Fedorenko V, Bechthold A, Luzhetskyy A, (2013) A transposon-based strategy to identify the regulatory gene network responsible for Landomycin E biosynthesis. FEMS-Letters 342(2), 138-46.
  58. Ma Z, Liu J, Bechthold A, Tao L, Bian Y, Yu X (2013)  Development of Intergeneric Conjugal Gene Transfer System in Streptomyces diastatochromogenes 1628 and Its Application for Improvement of Toyocamycin Production. Curr. Microbiology. 68(2):180-5.
  59. Strobel T, Schmidt Y, Linnenbrink A, Luzhetskyy A, Luzhetska M, Taguchi T, Brötz E, Paululat T, Stasevych M, Stanko O, Novikov V, Bechthold A (2013)  Tracking down biotransformation to the genetic level: Identfication of a highly flexible glycosyltransferase from Saccharothrix espanaensis. AEM. 79(17), 5224-5232.
  60. Kalan L, Gessner A, Szawiola A, Thaker A, Bechthold A, Wright G, Zechel D (2013) A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene. ChemBiol. 20, 1214-1224.
  61. Strobel T, Al'Dilaimi A, Blom J, Gessner A, Kalinowski J, Luzhetska M, Pühler A, Szczepanowsk R., Bechthold A, Rückert C (2012) Complete genome sequence of Saccharothrix espanaensis DSM 44229T and comparison to the other completely sequenced Pseudonocardiaceae. BMC Genomics 13, 465-478.
  62. Harder U, Luzhetska M, Ebeling S, Bechthold A (2012) Ethanol production in actinomycetes after expression of synthetic adhB and pdc. The Open Biotechnology Journal, 6, 13-16.
  63. Bechthold A, Yan X (2012) SnoaW/SnoaL2: a different two-component mono-oxygenase. ChemBiol., 19(5), 549-551.
  64. Horbal L, Rebets Y, Rabyk M, Makitrynskyy R, Luzhetskyy A, Fedorenko V, Bechthold A (2012) SimReg1 is a master switch for biosynthesis and export of Simocyclinone D8 and its precursors. AMB-Express, 2(1), 1-12.
  65. Yan X, Probst K, Linnenbrink A, Arnold M, Paulutat T, Zeeck A, Bechthold A (2012) Cloning and heterologous expression of three type II PKS gene clusters from Streptomyces bottropensis. ChemBioChem., 13(2), 224-230.
  66. Herrmann S, Siegl T, Luzhetska M, Petzke L, Jilg C, Welle E, Erb A, Leadlay P, Bechthold A, Luzhetskyy A (2012) Site-specific recombination strategies for engineering actinomycetes genomes. Appl Environ Microbiol., 78(6), 1804-1812.
  67. Erxleben A, Wunsch-Palasis J, Grüning B, Luzhetska M, Bechthold A, Günther S (2011) Genome sequence of Streptomyces sp. Strain Tü6071. J. Bacteriol. 193(16), 4278-4279.        
  68. Härle J, Günther S, Lauinger B, Weber M, Kammerer B, Zechel DL, Luzhetskyy A, Bechthold A (2011) Rational design of an aryl-C-glycoside catalyst from a natural product O-glycosyltransferase. ChemBiol.18(4), 520-530.
  69. Krohn K, Vidal A, Tran-Thien HT, Flörke U, Bechthold A, Dujardin G, Green I (2010) Total synthesis of silyl-protected early intermediates of polyketide biosynthesis. Eur. J. Org. Chem., 3080-3092.
  70. Ostash B, Ostash I, Zhu L, Kharel MK, Luzhetskyy A, Bechthold A, Walker S, Rohr J, Fedorenko V (2010) Properties of lank-based regulatory circuit involved in landomycin biosynthesuis in Streptomyces cyanogenus S136. Genetika46(5), 604-609.
  71. Daum M, Schnell HJ, Herrmann S, Günther A, Murillo R, Müller R, Bisel P, Müller M, Bechthold A (2010) Function of genes and enzymes involved in phenalinolactone biosynthesis. ChemBioChem.11(19), 1383-1391.
  72. Horbal L, Rebets Y, Rabyk M, Luzhetskyy A, Ostash B, Welle E, Nakamura T, Fedorenko V, Bechthold A (2010) Characterization and analysis of the regulatory network involved in control of lipomycin biosynthesis in Streptomyces aureofaciens Tü117. Appl Microbiol Biotechnol.85(4), 1069-1079.
  73. Rebets Y, Boll R, Horbal L, Fedorenko, V, Bechthold A (2009) Production of Avilamycin A is regulated by AviC1 and AviC2, two transcriptional activators. Journal of Antibiotics62(8), 461-464.
  74. Daum M, Peintner I, Linnenbrink A, Frerich A, Weber M, Paululat T, Bechthold A (2009) Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin.  Chembiochem.10(6), 1073-1083.
  75. Erb A, Luzhetskyy A, Hardter U, Bechthold A (2009) Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and the elucidation of the assembly of their saccharide chains. Chembiochem.10(8), 1392-1401.
  76. Krauth C, Fedoryshyn M, Schleberger C, Luzhetskyy A, Bechthold A (2009) Engineering a novel function into a glycosyltransferase. ChemBiol.16, 28-35.
  77. Erb A, Krauth C, Luzhetskyy A, Bechthold A (2009) Differences in the substrate specificity of glycosyltransferases involved in landomycins A and E biosynthesis. Appl. Microbiol. Biotechnol.70(15-16), 1812-1821.
  78. Luzhetskyy A, Hoffmann J, Pelzer S, Wohlert SE, Vente A, Bechthold A (2008) Aranciamycin analogs generated by combinatorial biosynthesis show improved antitumor activity. Appl. Microbiol. Biotechnol.80(1), 15-19.
  79. Ostash I, Ostash B, Luzhetskyy A, Bechthold A, Walker S, Fedorenko V (2008) Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136. FEMS Microbiol. Lett.285(2), 195-202.
  80. Fedoryshyn M, Petzke L, Welle E, Bechthold A, Luzhetskyy A (2008) Marker removal from actinomycetes genome using Flp recombinase. Gene419(1-2), 43-47.
  81. Fedoryshyn M, Welle E, Bechthold A, Luzhetskyy A (2008) Functional expression of the Cre recombinase in actinomycetes. Appl Microbiol Biotechnol78(6), 1165-1170.
  82. Rebets Y, Dutko L, Ostash B, Luzhetskyy A, Kulachkovskyy O, Yamaguchi T, Nakamura T, Bechthold A, Fedorenko V (2008) Function of lanI in regulation of landomycin A biosynthesis in Streptomyces cyanogenus S136 and cross-complementation studies with Streptomyces antibiotic regulatory proteins encoding genes. Arch Microbiol189(2), 111-120.
  83. Binz TM, Wenzel SC, Schnell HJ, Bechthold A, Müller R (2008) Heterologous expression and genetic engineering of the phenalinolactone biosynthetic gene cluster using Red/ET recombineering. ChemBioChem9(3), 447-454.
  84. Luzhetskyy A, Weiss H, Charge A, Welle E, Linnebrink A, Vente A, Bechthold A (2007) A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis. Appl Microbiol Biotechnol., 75(6), 1367-1375.
  85. Kopp M, Rupprath C, Irschik H, Bechthold A, Elling L, Müller R (2007) SorF: A glycosyltransferase with promiscuous donor substrate specificity in vitro.  Chembiochem7(8), 813-819.
  86. Luzhetskyy A, Mayer A, Hoffmann J, Pelzer S, Holzenkämper M, Schmitt B, Wohlert SE, Vente A, Bechthold A (2007) Cloning and Heterologous Expression of the Aranciamycin Biosynthetic Gene Cluster Revealed a New Flexible Glycosyltransferase. Chembiochem8(6), 599-602.
  87. Zhu L, Luzhetskyy A, Luzhetska M, Mattingly C, Adams V, Bechthold A, Rohr J (2007) Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136. Chembiochem8, 83-88.
  88. Mittler M, Bechthold A, Schulz GE (2007) Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin. J. Mol. Biol372, 67-76.
  89. Hornung A, Bertazzo M, Dziarnowski A, Schneider K, Welzel K, Wohlert SE, Holzenkampfer M, Nicholson GJ, Bechthold A, Süssmuth RD, Vente A, Pelzer S (2007) A genomic screening approach to the structure-guided identification of drug candidates from natural sources. Chembiochem8, 757-766.
  90. Fedoryshyn M, Nur-e-Alam, Zhu L, Luzhetskyy A, Rohr J, Bechthold A (2007) Surprising production of a new urdamycin derivative by S. fradiae Delta urdQ/R. J. Biotechnol.130, 32-38.
  91. Luzhetskyy A, Fedoryshyn M, Gromyko O, Ostash B, Rebets Y, Bechthold A, Fedorenko V (2006) IncP plasmids are most effective in mediating conjugation between Escherichia coli and streptomycetes. Genetika42, 595-601.
  92. Dutko L,  Rebets Y,  Ostash B, Luzhetskyy A, Bechthold A, Nakamura T, Fedorenko V (2006) A putative proteinase gene is involved in regulation of landomycin E biosynthesis in Streptomyces globisporus 1912. FEMS Microbiol. Lett.255, 280-285.
  93. Dürr C, Schnell HJ, Luzhetskyy A, Murillo R, Weber M, Welzel K, Vente A, Bechthold A (2006) Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tu6071: analysis of the gene cluster and generation of derivatives. Chem Biol13, 365-377.
  94. Boll R, Hofmann C, Heitmann B, Hauser G, Glaser S, Koslowski T, Friedrich T, Bechthold A (2006) The active conformation of avilamycin A is conferred by AviX12, a radical AdoMet enzyme. J. Biol Chem281, 14756-14763.
  95. Bihlmaier C, Welle E, Hofmann C, Welzel K, Vente A, Breitling E, Müller M, Glaser S, Bechthold A (2006) Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin. Antimicrob. Agents Chemother.50, 2113-2121.
  96. Berner M, Krug D, Bihlmaier C, Vente A, Müller R, Bechthold A (2006) Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis. J. Bacteriol.188, 2666-2673.
  97. Baig I, Kharel M, Kobylyanskyy A, Zhu L, Rebets Y, Ostash B, Luzhetskyy A, Bechthold A, Fedorenko VA, Rohr J (2006) On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2). Angew. Chem Int. Ed Engl., 45, 7842-7846.
  98. Zhu L, Ostash B, Rix U, Nur-e-Alam, Mayers A, Luzhetskyy A, Mendez C, Salas JA, Bechthold A, Fedorenko V, Rohr J (2005) Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone. J. Org.  Chem70, 631-638.
  99. Treede I, Hauser G, Mühlenweg A, Hofmann C, Schmidt M, Weitnauer G, Glaser S, Bechthold A (2005) Genes involved in formation and attachment of a two-carbon chain as a component of eurekanate, a branched-chain sugar moiety of avilamycin A. Appl. Environ. Microbiol.71, 400-406.
  100. Rebets Y, Ostash B, Luzhetskyy A, Kushnir S, Fukuhara M, Bechthold A, Nashimoto M, Nakamura T, Fedorenko V (2005) DNA-binding activity of LndI protein and temporal expression of the gene that upregulates landomycin E production in Streptomyces globisporus 1912. Microbiology151, 281-290.
  101. Ostash BE, Ogonian SV, Luzhetskyy AN, Bechthold A, Fedorenko VA (2005) [The use of PCR for detecting genes that encode type I polyketide synthases in genomes of actinomycetes]. Genetika41, 595-600.
  102. Mosbacher TG, Bechthold A, Schulz GE (2005) Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes. J. Mol. Biol345, 535-545.
  103. Mayer A, Taguchi T, Linnenbrink A, Hofmann C, Luzhetskyy A, Bechthold A (2005) LanV, a bifunctional enzyme: aromatase and ketoreductase during landomycin A biosynthesis. Chembiochem6, 2312-2315.
  104. Luzhetskyy A, Fedoryshyn M, Dürr C, Taguchi T, Novikov V, Bechthold A (2005) Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A. Chem Biol12, 725-729.
  105. Luzhetskyy A, Bechthold A (2005) It works: combinatorial biosynthesis for generating novel glycosylated compounds. Mol. Microbiol.58, 3-5.
  106. Luzhetskyy A, Zhu L, Gibson M, Fedoryshyn M, Dürr C, Hofmann C, Hoffmeister D, Ostash B, Mattingly C, Adams V, Fedorenko V, Rohr J, Bechthold A (2005) Generation of novel landomycins M and O through targeted gene disruption. Chembiochem6, 675-678.
  107. Luzhetskyy A, Taguchi T, Fedoryshyn M, Dürr C, Wohlert SE, Novikov V, Bechthold A (2005) LanGT2 Catalyzes the First Glycosylation Step during landomycin A biosynthesis. Chembiochem6, 1406-1410.
  108. Hofmann C, Boll R, Heitmann B, Hauser G, Dürr C, Frerich A, Weitnauer G, Glaser SJ, Bechthold A (2005) Genes encoding enzymes responsible for biosynthesis of L-lyxose and attachment of eurekanate during avilamycin biosynthesis. Chem Biol12, 1137-1143.
  109. Bechthold A (2005) Exploiting Pseudomonas putida for drug development. Chem Biol12, 261.
  110. Weitnauer G, Hauser G, Hofmann C, Linder U, Boll R, Pelz K, Glaser SJ, Bechthold A (2004) Novel avilamycin derivatives with improved polarity generated by targeted gene disruption. Chem Biol11, 1403-1411.
  111. Von Mulert U, Luzhetskyy A, Hofmann C, Mayer A, Bechthold A (2004) Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene. FEMS Microbiol. Lett.230, 91-97.
  112. Luzhetskyy A, Liu T, Fedoryshyn M, Ostash B, Fedorenko V, Rohr J, Bechthold A (2004) Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis. Chembiochem5, 1567-1570.
  113. Hoffmeister D, Weber M, Drager G, Ichinose K, Dürr C, Bechthold A (2004) Rational saccharide extension by using the natural product glycosyltransferase LanGT4.Chembiochem5, 369-371.
  114. Gromyko O, Rebets Y, Ostash B, Luzhetskyy A, Fukuhara M, Bechthold A, Nakamura T, Fedorenko V (2004) Generation of Streptomyces globisporus SMY622 strain with increased landomycin E production and its initial characterization. J. Antibiot. (Tokyo)57, 383-390.
  115. Eichhorn P, Perez S, Bechthold A, Aga, D.S. (2004) Fragmentation studies on the antibiotic avilamycin A using ion trap mass spectrometry 107. Journal of Mass Spectrometry39, 1541-1553.
  116. Dürr C, Hoffmeister D, Wohlert SE, Ichinose K, Weber M, Von Mulert U, Thorson JS, Bechthold A (2004) The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers. Angew. Chem Int. Ed Engl.43, 2962-2965.
  117. Treede I, Jakobsen L, Kirpekar F, Vester B, Weitnauer G, Bechthold A, Douthwaite S (2003) The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose. Mol. Microbiol.49, 309-318.
  118. Rix U, Remsing LL, Hoffmeister D, Bechthold A, Rohr J (2003) Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717. Chembiochem4, 109-111.
  119. Rebets Y, Ostash B, Luzhetskyy A, Hoffmeister D, Brana A, Mendez C, Salas JA, Bechthold A, Fedorenko V (2003) Production of landomycins in Streptomyces globisporus 1912 and S cyanogenus S136 is regulated by genes encoding putative transcriptional activators. FEMS Microbiol. Lett.222, 149-153.
  120. Mosbacher TG, Bechthold A, Schulz GE (2003) Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes.  J. Mol. Biol329, 147-157.
  121. Hoffmeister, D., Drager, G., Ichinose, K., Rohr, J., Bechthold, A. (2003) The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses. J. Am. Chem Soc.125, 4678-4679.
  122. Weitnauer G, Gaisser S, Kellenberger L, Leadlay PF, Bechthold A (2002) Analysis of a C-methyltransferase gene (aviG1) involved in avilamycin biosynthesis in Streptomyces viridochromogenes Tu57 and complementation of a Saccharopolyspora erythraea eryBIII mutant by aviG1. Microbiology148, 373-379.
  123. Trefzer A, Pelzer S, Schimana J, Stockert S, Bihlmaier C, Fiedler HP, Welzel K, Vente A, Bechthold A (2002) Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic. Antimicrob. Agents Chemother.46, 1174-1182.
  124. Trefzer A, Blanco G, Remsing L, Kunzel E, Rix U, Lipata F, Brana AF, Mendez C, Rohr J, Bechthold A, Salas JA (2002) Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways. J. Am. Chem Soc.124, 6056-6062.
  125. Luzhetskyy A, Fedoryshyn M, Hoffmeister D, Bechthold A, Fedorenko V (2002) A gene cloning system for Streptomyces cyanogenus S136. Biovinsky (Ukraine), 29, 62-68.
  126. Hoffmeister D, Wilkinson B, Foster G, Sidebottom PJ, Ichinose K, Bechthold A (2002) Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity. Chem Biol9, 287-295.
  127. Yazaki K, Matsuoka H, Shimomura K, Bechthold A, Sato F (2001) A novel dark-inducible protein, LeDI-2, and its involvement in root-specific secondary metabolism in Lithospermum erythrorhizon. Plant Physiol125, 1831-1841.
  128. Weitnauer G, Gaisser S, Trefzer A, Stockert S, Westrich L, Quiros LM, Mendez C, Salas JA, Bechthold A (2001) An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57. Antimicrob. Agents Chemother.45, 690-695.
  129. Weitnauer G, Mühlenweg A, Trefzer A, Hoffmeister D, Süssmuth RD, Jung G, Welzel K, Vente A, Girreser U, Bechthold A (2001) Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 and production of new antibiotics. Chem Biol8, 569-581.
  130. Trefzer A, Fischer C, Stockert S, Westrich L, Kunzel E, Girreser U, Rohr J, Bechthold A (2001) Elucidation of the function of two glycosyltransferase genes (lanGT1 and lanGT4) involved in landomycin biosynthesis and generation of new oligosaccharide antibiotics. Chem Biol8, 1239-1252.
  131. Hoffmeister D, Ichinose K, Bechthold A (2001) Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity. Chem Biol8, 557-567.
  132. Blanco G, Patallo EP, Brana AF, Trefzer A, Bechthold A, Rohr J, Mendez C, Salas JA (2001) Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin. Chem Biol8, 253-263.
  133. Trefzer A, Hoffmeister D, Kunzel E, Stockert S, Weitnauer G, Westrich L, Rix U, Fuchser J, Bindseil KU, Rohr J, Bechthold A (2000) Function of glycosyltransferase genes involved in urdamycin A biosynthesis. Chem Biol7, 133-142.
  134. Hoffmeister D, Ichinose K, Domann S, Faust B, Trefzer A, Drager G, Kirschning A, Fischer C, Kunzel E, Bearden D, Rohr J, Bechthold A (2000) The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster. Chem Biol7, 821-831.
  135. Faust B, Hoffmeister D, Weitnauer G, Westrich L, Haag S, Schneider P, Decker H, Kunzel E, Rohr J, Bechthold A (2000) Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717. Microbiology146(Pt 1), 147-154.
  136. Westrich L, Domann S, Faust B, Bedford D, Hopwood DA, Bechthold A (1999) Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis. FEMS Microbiol. Lett.170, 381-387.
  137. Trefzer A, Salas JA, Bechthold A (1999) Genes and enzymes involved in deoxysugar biosynthesis in bacteria. Nat Prod. Rep.16, 283-299.
  138. Sommer S, Kohle A, Yazaki K, Shimomura K, Bechthold A, Heide L (1999) Genetic engineering of shikonin biosynthesis hairy root cultures of Lithospermum erythrorhizon transformed with the bacterial ubiC gene. Plant Mol. Biol39, 683-693.
  139. Kunzel E, Faust B, Oelkers , Weissbach, U, Bearden DW, Weitnauer G, Westrich L, Bechthold A, Rohr J (1999) Inactivation of the urdGT2 gene, which encodes a glycosyltransferase responsible for the C-glycosyltransfer of activated D-olivose, leads to formation of the novel urdamycins I, J, and K
    106. Journal of the American Chemical Society121, 11058-11062.
  140. Bechthold A, Domann S, Faust B, Hoffmeister D, Stockert S, Trefzer A, Weitnauer G, Westrich L (1999) Glycosidierte Naturstoffe, Perspektiven für die Kombinatorische Biosynthese. Chemotherapie Journal4, 130-135.
  141. Sommer S, Siebert M, Bechthold A, Heide L (1998) Specific induction of secondary product formation in transgenic plant cell cultures using an inducible promoter. Plant Cell Reports17, 891-896.
  142. Li SM, Bechthold A, Heide L (1998) A 732 bp PCR fragment obtained from genomic DNA of the Boraginaceae plant Lithospermum erythrorhizon showed 38,1 % homology to a retrovirus-related polyprotein from Nicotiana tabacum. Plant Molecular Biology38, 505.
  143. Lange BM, Severin K, Bechthold A, Heide L (1998) Regulatory role of microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase for shikonin biosynthesis in Litho-spermum erythrorhizon cell suspension cultures. Planta204, 234-241.
  144. Ichinose K, Bedford DJ, Tornus D, Bechthold A, Bibb MJ, Revill WP, Floss HG, Hopwood DA (1998) The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host. Chem Biol5, 647-659.
  145. Westrich L, Gaisser S, Reichenstein B, Bechthold A (1997) Preparation and screening of cosmid libraries from Streptomyces strains using the rapid DNA ligation kit, digoxigenin labeling and detection kit from Boehringer Mannheim. Biochemica101, 30-32.
  146. Yazaki K, Bechthold A, Tabata M (1997) Molecular Cloning and Expression of a cDNA Encoding a WrbA homologue (Accession No. D45900) from Lithospermum erythrorhizon. Plant Gene Register PGR 97-159115, 1287.
  147. Gaisser S, Trefzer A, Stockert S, Kirschning A, Bechthold A (1997) Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes Tu57. J. Bacteriol.179, 6271-6278.
  148. Decker H, Gaisser S, Pelzer S, Schneider P, Westrich L, Wohlleben W, Bechthold A (1996) A general approach for cloning and characterizing dNDP-glucose dehydratase genes from actinomycetes. FEMS Microbiol. Lett.141, 195-201.
  149. Yazaki K, Bechthold A, Tabata M (1995) Nucleotide sequence of a cDNA from Lithospermum erythrorhizon homologous to PR-1 of parsley. Plant Physiol108, 1331-1332.
  150. Bechthold A, Sohng JK, Smith TM, Chu X,  Floss HG (1995) Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin. Mol. Gen. Genet.248, 610-620.
  151. Bechthold A, Floss HG (1994) Over-expression of the thiostrepton-resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2'-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA. Eur. J. Biochem., 224, 431-437.
  152. Heide L, Melzer M, Siebert M, Bechthold A, Schroder J, Severin K (1993) Clarification of the Escherichia coli genetic map in the 92-minute region containing the ubiCA operon and the plsB, dgk, lexA, and dinF genes. J. Bacteriol., 175, 5728-5729.
  153. Siebert M, Bechthold A, Melzer M, May U, Berger U, Schroder G, Schroder J, Severin K, Heide L (1992) Ubiquinone biosynthesis. Cloning of the genes coding for chorismate pyruvate-lyase and 4-hydroxybenzoate octaprenyl transferase from Escherichia coli. FEBS Lett., 307, 347-350.
  154. Bechthold A, Berger U, Heide L (1991) Partial purification, properties, and kinetic studies of UDP-glucose:p-hydroxybenzoate glucosyltransferase from cell cultures of Lithospermum erythrorhizon. Arch. Biochem. Biophys., 288, 39-47.
  155. Bechthold A, Heide L, Tabata M (1989) P Hydroxybenzoic Acid Glucosyltransferase An Enzyme Related to Shikonin Biosynthesis in Cell Cultures of Lithospermum-Erythrorhizon. Planta Medica55, 684-685.


  1. Ostash B, Yan X, Fedorenko V, Bechthold A (2010) Chemoenzymatic and bioenzymatic synthesis of carbohydrate containing natural products. Top. Curr. Chem., 297, 105-148.
  2. Härle J, Lauinger B, Dietmann K, Bechthold A (2010) Maßgeschneiderte Biokatalysatoren für eine süßere Chemie. Biospektrum, 3, 306-307.
  3. Luzhetska M, Härle J, Bechthold A (2010) Combinatorial and synthetic biosynthesis in actinomycetes. Fortschr Chem Org Naturst., 93, 211-237.
  4. Bechthold A, Probst K (2010) Glycosylation of secondary metabolites to produce novel compounds. 3rd edition of the Manual of Industrial Microbiology and Bio-technology. Eds. Baltz, R.H., Demain, A.L., Davies, J.E., 347-364.
  5. Erb A, Weiß H, Härle J, Bechthold A (2009) A glycosyltransferase gene toolbox: generation and applications. Phytochemistry, 70(15-16), 1812-1821.
  6. Daum M, Herrmann S, Wilkinson B, Bechthold A (2009) Genes and Enzymes Involved in Bacterial Isoprenoid Biosynthesis. Curr Opin Chem Biol., 13(2), 180-8.
  7. Härle J, Bechthold A (2009) The power of Glycosyltransferases to generate bioactive natural compounds. Methods Enzymol., 458, 309-33.
  8. Luzhetskyy A, Bechthold A (2008) Features and applications of bacterial glycosyltransferases: current state and prospects. Appl. Microbiol. Biotechnol., 80(6), 945-52.
  9. Luzhetskyy A, Méndez C, Salas J, Bechthold A (2008) Glycosyltransferases, important tools for drug design. Curr. Med. Chem., 8(8), 680-709.
  10. Méndez C, Luzhetskyy A, Bechthold A, Salas J (2008) Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern. Curr. Med. Chem., 8(8), 710-724.
  11. Luzhetskyy A, Pelzer S, Bechthold A (2007) The future of natural products as a source of new antibiotics. Curr. Opin. Investig. Drugs, 8, 608-613.
  12. Hertweck C, Luzhetskyy A, Rebets Y, Bechthold A (2007) Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. Nat Prod. Rep., 24, 162-190.
  13. Pelzer S, Vente A, Bechthold A (2005) Novel natural compounds obtained by genome-based screening and genetic engineering. Curr. Opin. Drug Discov. Devel., 8, 228-238.
  14. Merfort A, Pelzer S, Hoffmeister D, Bechthold A (2005) Procaryotic and eucaryotic cells in biotech production. Encyclopedia of Molecular Cell Biology and Molecular Medicine.
  15. Luzhetskyy A, Vente A, Bechthold A (2005) Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides. Mol. Biosyst., 1, 117-126.
  16. Hoffmeister D, Pelzer S, Wohlleben W, Bechthold A (2002) Herstellung neuer Naturstoffe durch Kombinatorische Biosynthese. Biospektrum, Sonderausgabe, 508-510.
  17. Bechthold A, Vente A (2002) Recent advances in combinatorial biosynthesis. Euro-Biotech, 24-25.
  18. Bechthold A (2001) Glycosylated antibiotics: Studies on genes involved in deoxysugar formation, modification and attachment, and their use in combinatorial biosynthesis. In: Braun, V., Götz, F.: Microbial fundamentals of biotechnology (Deutsche Forschungs-gemeinschaft); Wiley-VCH, Weinheim, 124-138.
  19. Mendez C, Weitnauer G, Bechthold A, Salas JA (2000) Structure alteration of polyketides by recombinant DNA technology in producer organisms-prospects for the generation of novel pharmaceutical drugs. Curr. Pharm. Biotechnol., 1, 355-395.
  20. Weitnauer G, Bechthold A (1999) Antibiotika im Blickpunkt - Verbot des Einsatzes von Spiramycin, Tylosin und Bacitracin als Wachstumsförderer in der Tiermast. PZ - Prisma, 2, 117-125.
  21. Trefzer A, Salas JA, Bechthold A (1999) Genes and enzymes involved in deoxysugar biosynthesis in bacteria. Nat Prod. Rep., 16, 283-299.
  22. Holzgrabe U, Bechthold A (1999) Paradigmenwechsel in der Entwicklung antiinfektiver Chemotherapeutika - Neue Methoden zur Entwicklung neuer Leitstrukturen. Chemotherapie Journal, 2, 69-81.
  23. Hoffmeister D, Bechthold A (1999) Halten wir Schritt mit den Mikroben? - Die Suche nach neuen Antibiotika. PZ - Prisma, 3, 185-194.
  24. Bechthold A (1997) Streptomycetengenetik, Grundlage für die Herstellung neuer Antibiotika. Pharmazie in unserer Zeit, 26, 12-16.
  25. Heide L, Bechthold A, Yazaki K, Tabata M (1992) Enzymes of shikonin biosynthesis in Lithospermum erythrorhizon cell cultures. Plant Tissue Culture and Gene Manipulation for Breeding and Formation of Phytochemicals, 254.

Bücher und Buchbeiträge 

  1. Bechthold A, Fürst R, Vollmar A (2019) Biogene Arzneistoffe. Wissenschaftliche Verlagsgesellschaft Stuttgart.
  2. Zhang S, Bechthold A (2016) Iteratively acting glycosyltransferases. In: Grunwald, P.: Carbohydrate-Modifying Biocatalysts, Pan Stanford Publishing, Singapore, 321-348.
  3. Bechthold A (2013) Pharmazeutische Biotechnologie kompakt. Wissenschaftliche Verlagsgesellschaft Stuttgart, in press
  4. Bechthold A (2012) Pharmazeutische Mikrobiologie kompakt. Wissenschaftliche Verlagsgesellschaft Stuttgart.
  5. Luzhetskyy A, Weitnauer G, Bechthold A (2012) Prokaryotic cells in biotech production. In: Kayser O, Warzecha H: Pharmaceutical Biotechnology, Wiley Blackwell, Weinheim
  6. Luzhetska M, Bechthold A (2011) Iteratively acting glycosyltransferases. In: Grunwald P: Carbohydrate-Modifying Biocatalysts, Pan Stanford Publishing, Singapore, 255-269.
  7. Bechthold A, Vollmar A, Wagner H (2007) Pharmazeutische Biologie 2, 7. Auflage. Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart.
  8. Bechthold A, Weitnauer G, Luzhetskyy A, Berner M, Bihlmaier C, Boll R, Dürr C, Frerich A, Hofmann C, Mayer A, Treede I, Vente A, Luzhetskyy M (2005) Glycosyltransferases and other tailoring enzymes as tools for the generation of novel compounds. In: Ernst Schering Res. Found. Workshop. 51,147-163.
  9. Hoffmeister D, Bechthold A (2005) In: Aktories, Giftpflanzen, Pflanzengifte, Pilzgifte (in: Förstermann, Hofmann, Starke (Eds.:); Allgemeine und spezielle Pharmakologie und Toxikologie. Urban & Fischer Verlag, München, Jena,1073-1089.
  10. Pelzer S, Hoffmeister D, Merfort I, Bechthold A (2004) Procrayotic and eucaryotic cells in biotech production. In: Kayser O, Müller RH (eds.) Pharmaceutical Biotechnology, Drug Discovery and Clinical Applications. Wiley-VCH-Weinheim, 9-33.
  11. Bechthold A (2000) Molekularbiologische Arbeitsmethoden zur Analytik biogener Arzneistoffe. In: Adam KP und Becker H (Eds.): Analytik biogener Arzneistoffe. G. Fischer-Verlag, Stuttgart, 269-285.
  12. Bechthold A, Salas JA (1999) Combinatorial biosynthesis of microbial metabolites. In: Jung, G. (ed.): Combinatorial organic chemistry. Wiley-VCH, Weinheim, 381-407.
  13. Wohlert S, Bechthold A, Beninga C, Henkel T, Holzenkämpfer M, Kirschning A, Oelkers C, Weber S, Weißbach U, Westrich L, Rohr J (1999) Investigation on the biosynthesis of landomycin A. (in: Diederichsen U, Lindhorst ThK, Wessjohann L, Westermann B (ed.). New aspects in Bioorganic Chemistry, Wiley-VCH, 305-312.
  14. Bechthold A, Rohr J (1999) Oligosaccharide antibiotics, perspective for combinatorial biosynthesis. (in: Diederichsen U, Lindhorst ThK, Wessjohann L, Westermann B (e.d). New aspects in Bioorganic Chemistry, Wiley-VCH, Weinheim, 313-321.
  15. Kirschning A, Bechthold A, F-W, Rohr J (1997) Chemical and biochemical aspects of deoxysugars and deoxysugar oligosaccharides. Bioorganic Chemistry Deoxysugars, Polyketides and Related Classes: Synthesis, Biosynthesis, Enzymes, Vol. 188, 1-84.
  16. Wohlleben W, Pelzer S, Bechthold A, Decker H (1996) Identifizierung von Sekundärmetabolit-Produzenten durch „genetisches Screening“. Dechema-Jahrestagung 96, Band I,127.
  17. Decker H, Pelzer S, Wohlleben W, Bechthold A (1996) Identifizierung von Produzenten von Sekundärmetaboliten mit 6-Desoxyzuckern als Bestandteil durch „genetisches Screening“. Dechema-Jahrestagung 96, Band I, 131. 

1.     Liao Z, Song Z, Xu J, Ma Z, Bechthold A, Yu X (2020) Identification of a gene from Streptomyces rimosus M527 negatively affecting antibiotic biosynthesis and morphological differentiation. Applied Microbiol Biotechnol 104 (23): 10191-10202